Ben's fiancée has her heart set on an expensive dream wedding, but her father, Jack, has secretly gambled away all his money. When Ben discovers he has a talent for exotic dancing, Jack pushes him to moonlight as a stripper to finance the wedding.

In the not too distant future a secret government re-animation chemo-virus gets released into conservative Sartre, Nebraska and lands in an underground strip club. As the virus begins to spread, turning the strippers into "Super Zombie Strippers" the girls struggle with whether or not to conform to the new "fad" even if it means there's no turning back.