Inspired by the true story of University of Virginia basketball star Lamont Carr, the film centers on a group of young Jewish basketball players who search for a coach to help them out of a slump. The main character Alex Schlotsky is inspired by the true story of Alex Barbag and Chad Korpeck.

Cady Heron is a hit with The Plastics, the A-list girl clique at her new school, until she makes the mistake of falling for Aaron Samuels, the ex-boyfriend of alpha Plastic Regina George.