Two go-go dancers, Lulu and Peaches, are framed for the murder of their employer by the real killer, sleazy gangster Vinnie. Picking up waitress Darlene along the way, the three are involved in wild car chases with cops as they head south to cross the border into Mexico, where they unexpectedly encounter Vinnie in a fleabag Mexican motel.

After being exposed to a bizarre mixture of household chemicals, Pat Kramer begins to shrink. This baffles scientists, makes parenting difficult, warms the hearts of Americans, and captures the attention of a group of people who want to take over the world. This evil group plots to kidnap Pat and perform experiments on her so that they can eventually shrink everyone.