A man named Seligman finds a fainted wounded woman in an alley and he brings her home. She tells him that her name is Joe and that she is nymphomaniac. Joe tells her life and sexual experiences with hundreds of men since she was a young teenager while Seligman tells about his hobbies, such as fly fishing, reading about Fibonacci numbers or listening to organ music.

Marko Stemper, 19 years old, comes from a disadvantaged background and works as a window cleaner. His father, an alcoholic, tyrannizes the whole family, so Marko's only joy in life is boxing. As he is the most promising talent in his club, Gerd Hermsbach, a local demimonde boss, offers him the opportunity to become a professional. Marko accepts, but has to pay a high price...

Notoriously hip Berlin based hairdresser Tom Herzner falls in love with beauty parlor owner Heidi, turning both of their worlds upside down. So far so good. Only one problem: Tom is gay.

The film tells the story of Faust who unites with the devil in search of ultimate wisdom. He realizes too late, that winning Gretchen's heart with the devil's help means destroying her life.