Then Sings My Soul tells the story of seven women who discover that their lives are interconnected as they find deliverance.

When a job opportunity opens up for newlywed Grant Himmel, he moves with his wife Christie out to the countryside in Courtland, Virginia. However, Christie finds life in her new house to be unsettling. The area has a history of violence and it is where the exile of the Cheroenhaka Native Americans took place; no one in the area talks about the exile however. After several strange encounters, Christie believes that the house she is living in is haunted; nobody believes her however. Then, when Christie discovers the truth behind what is really going on, she finds that she is already trapped in her house.

A married woman, Natalie, becomes pregnant after she is violently raped by a masked man. Uncertain of the paternity, Natalie's husband, Pat, urges her to have an abortion. Afterwards the couple is left to deal with the emotional aftermath as they try to rebuild their lives.