Ten years after graduation, a mini-reunion is organized by Tom and Jill Miller at their home, inviting only the special friends that were in their clique and one fringe member, Bobby Zwick, whom they had done a terrible wrong. Bobby said all was forgiven, but he was not telling the truth.

When Detective Sarah takes in her troubled teenage niece Emily, she discovers a dark family secret: Emily carries the curse of the Blue Moon. As the full moon rises, Sarah is forced into a dangerous world of bloodlines, betrayals, and supernatural forces that threaten to tear them apart. Howl of the Blue Moon is a haunting supernatural crime drama that explores loyalty, sacrifice, and the thin line between humanity and the monster within.