In the main event, former UFC heavyweight champion Junior dos Santos will square off against fellow UFC veteran Yorgan De Castro in a heavyweight contest. Dos Santos will be competing for the first time since his departure from the UFC in early 2021. De Castro won his Eagle FC debut in January with a first-round guillotine over Shaun Asher in 64 seconds.

The PFL 7 mixed martial arts event for the 2021 season of the Professional Fighters League was held on August 13, 2021. This was the start of the playoffs for the Welterweight and Lightweight divisions. This event aired on ESPN2, with the prelims on ESPN+.

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UFC on Fox 19: Teixeira vs. Evans was a mixed martial arts event held on April 16, 2016 at Amalie Arena in Tampa, Florida. The event was the second that the organization has hosted in the Tampa Bay Area, and first since UFC Fight Night: Lauzon vs. Stephens in February 2009.

UFC Fight Night 112: Chiesa vs. Lee was a mixed martial arts event produced by the Ultimate Fighting Championship held on June 25, 2017, at Chesapeake Energy Arena in Oklahoma City, Oklahoma. A lightweight bout between The Ultimate Fighter: Live lightweight winner Michael Chiesa and Kevin Lee served as the event headliner.

The Ultimate Fighter: Heavy Hitters Finale (also known as The Ultimate Fighter 28 Finale) was a mixed martial arts event produced by the Ultimate Fighting Championship held on November 30, 2018 at Pearl Theatre at Palms Casino Resort in Las Vegas, Nevada, United States. A welterweight bout between former UFC Lightweight Champion Rafael dos Anjos and The Ultimate Fighter: American Top Team vs. Blackzilians welterweight winner Kamaru Usman served as the event headliner.