After neutralizing the original curse, Guido, the jewel smuggler who was the only gangster to survive the shoot out in the warehouse, has learned that the spirits of those who were deceased in the gunfight have returned to once again torment the ladies. Guido must know gather himself and figure out who is responsible for the black magic that has brought back the curse.

When a group of well-meaning archaeology students unearth an ancient jewel box in Southern California's Burbank mountains, they unleash a deadly curse that turns perfectly normal women into maniacal, bloodthirsty cannibals.