Leo and Angela Russo live a simple life in Queens, surrounded by their overbearing Italian-American family. When their son finds success on his high school basketball team, Leo tears the family apart trying to make it happen.

Following an abrupt breakup with her long-term boyfriend Justin, Amber finds a splinter buried in her hand. The wound soon becomes infected and swollen, evolving into Hand—a persistent and painful presence that grows increasingly grotesque. Deciding to ignore it, Amber fixates on the stains Justin left on the carpet over the course of their relationship. As her obsession intensifies, so does the seriousness of her infection.