Girolamo, a teenager from a good family suffering from bone tuberculosis, is hospitalized in a sanatorium where he is forced to suffer the harassment of his rough roommate, sadistically backed by an Austrian nurse. To alleviate his suffering a little will be the tender friendship with Polly, a sweet English girl.

Peter Goodrich, an English antique dealer visiting Naples for a pleasure trip, meets the beautiful Lisa Carter by chance and begins seeing her until the woman disappears.

Young Franco is imprisoned for murder and rises to become the feared and powerful 'Professor', taking control of Naples' underworld from behind bars.