Jack, a failing writer, spends his days waiting for his big break. But when that day arrives with a lost tooth, he begins to spiral into a habit of self-mutilation and delusion.

Having just robbed a bank, glass cannon Beau Cotton and hired gun Wyatt Rider attempt to escape over the Mexican border. They are pursued by Sheriffs donning executioner hoods who want to murder Beau for his mixed heritage. As the sheriffs gain ground on the two, their grievances clash together to stall them even further.

Cancer-ridden Private Investigator Arthur Marshall is hired to seek out a sex worker, the twin sister of the enigmatic Luna Vesper. As the case develops, so to do Arthur's tumours, and he soon finds himself in a dark underworld that forces him to reflect on his mortality.