Doctor Strange, with the help of mystical allies both old and new, traverses the mind-bending and dangerous alternate realities of the Multiverse to confront a mysterious new adversary.

Before Alice went to Wonderland, and before Peter became Pan, they were brother and sister. When their eldest brother dies in a tragic accident, they each seek to save their parents from their downward spirals of despair until finally they are forced to choose between home and imagination, setting the stage for their iconic journeys into Wonderland and Neverland.