Jack Gladney, professor of Hitler studies at The-College-on-the-Hill, husband to Babette, and father to four children/stepchildren, is torn asunder by a chemical spill from a rail car that releases an "Airborne Toxic Event" forcing Jack to confront his biggest fear - his own mortality.

Joe, a down-on-his-luck truck driver haunted by the memory of his deceased wife and child, meets Julie, a spiritually gifted woman who enlists his help in a desperate effort to find the lost soul of her comatose daughter. But the spirit of Joe's dead wife proves stronger, possessing the young woman's body and determined to settle her unfinished business with the living.

After a masked intruder assaults Morgan Metzer in her home, her estranged husband, Rodney, shows up minutes later. Questioned by the authorities, Rodney's story doesn't seem to add up, making him the prime suspect in the attack.