As a director and his crew shoot a controversial film about Christopher Columbus in Cochabamba, Bolivia, local people rise up against plans to privatize the water supply.

While Carlos, a banking executive, takes his two kids to school in his car, he gets a phone call telling him that there is a bomb under the seats and he must to gather a large amount of money; otherwise, his car will blow up.

Mario, an exemplary man, lives in a village on the Galician coast. In the old people’s home, where he works as a nurse, everyone appreciates him. When the best known narco in the area, Antonio Padín, recently released from prison, enters the residence, Mario tries to make Antonio feel at home. Now, Padín's two sons, Kike and Toño, are in charge of the family business. The failure of an operation will put Kike in jail and cause them to owe a large debt to a Colombian supplier. Toño will turn to the nurse to try to convince his father to assume the debt. But Mario has his own plans.

A variant of the rabies virus has infected the global population. Now, in a world full of infected people, three siblings do everything they can to survive and reunite.