After a drunken evening and an unforgettable night with a total stranger, Manu wakes up alone to find a message on his arm giving him an appointment in Avignon. Convinced that the appointment is with the dreamy woman from the night before, he is ready to do anything to find her again.

After 20 years away, Isabelle, a former climbing champion, returns to her village in the Alps for the funeral of her mountain-guide father. She decides to open up a new climbing route with the help of Kenza, her protégé - something she'd planned to do with her father. But the past and its secrets resurface through Antoine, a brilliant mountaineer who was Isabelle's first love.

Three women from Brest. Léanne, the cop, a hothead whose ambition knows no bounds. Élodie, the forensic pathologist, a settled family woman. Vanessa, the psycho-criminologist, a fiercely independent and outspoken woman. Three childhood friends reunited since Léanne's recent return to Brittany following the death of her husband during an operation. Together, and despite their radically different personalities, they will hunt down the region's criminals while juggling their lives as women, trying their best to balance their work, family life, love, and friendships…