Charlie Baxter, a struggling screenwriter, is searching for accommodation in a rundown mansion somewhere in the isolated mountains above Malibu. An expressionless and creatively bankrupt young man who rewrites exploitation sci-fi / horror scripts for a living, he takes a room in the mansion and learns of the mysterious doctor residing in the room above his own who dabbles in strange experiments. As he learns more about the circumstances of the doctor and the history of his landlady, her autistic daughter and the strange lodger across the hall, Baxter is inspired to write his long blocked "great American Screenplay". Working furiously, Baxter suffers a heart attack, and staggers up to see the doctor for treatment. He passes out immediately, but awakens a cured man. But at a terrible price.

The devastating story of brothers Lafayette and Pharoah Rivers, children of the Chicago ghetto, is powerfully told here by a Wall Street Journal reporter who first met the boys in 1985 when they were 10 and 7, respectively. Their family includes a mother, a frequently absent father, an older brother, and younger triplets. We witness the horrors of growing up in an ill-maintained housing project tyrannized by drug gangs and where murders and shootings frequently occur.

Earl Pilcher Jr. runs an equipment rental outfit in Arkansas, lives with his wife and kids and parents, and rarely takes off his gimme cap. His mother dies, leaving a letter explaining he's not her natural son, but the son of a Black woman who died in childbirth; plus, he has a half brother Ray, in Chicago, she wants him to visit. Earl makes the trip, initially receiving a cold welcome from Ray and Ray's son, Virgil. His birth mother's sister, Aunt T., an aged and blind matriarch, takes Earl in tow and insists that the family open up to him.