At a college in Rome, a professor, nicknamed "Dodo" is in a deep depression. His stunningly beautiful wife has just left him for another man. Dodo wants her back very badly and has erotic daydreams about her. A beautiful young student in his class asks him for a ride home and seduces the lucky man, but still he wonders about his wife and her lover.

Kreola arrives in Santa Domingo to join her photographer husband Andy. Although Andy is initially jealous of Marco, who is in town looking for his missing girlfriend who did not return from Santa Domingo with her coworkers after a girls getaway. When Kreola and Andy site the missing girl Iris in the company of their gruff, dominating sea captain Leon, Andy suggests Kreola distract him so that Marco has a chance of getting Iris back. Kreola scoffs at this but eventually does fall under Leon's spell. Andy's writer friend Jo Ann blames the island atmosphere for the tendency for puritanical Westerners to reject their inhibitions. When Andy and Marco cannot free their women from Leon's influence, things get drastic.

The life of a rootless insurance agent starts falling apart.

The beauty and the attractiveness of her lover prevent a professional from getting the promotion that has always been coveted. Then a ferocious killer attentive to the woman's life.

7 segments about life in 1990s Italy: two MPs from the opposite sides of the political spectrum spend the night together; during their honeymoon, a woman cheats on her husband with her favorite soap opera star; a married man pretends to be ill to seduce his younger nurse; a family discovers that their son's beautiful fiancée is transgender; an unsatisfied single woman is duped by her celebrity crush for Kevin Costner; two best friends want to have fun; a couple on a tropical holiday is fascinated by their indigenous masseuse.

Although the drug is present in this film, the Crack this movie is about is, metaphorically, the crack in society which all the protagonists inhabit in a rundown neighborhood in Rome.