When the father of sixteen-year-old Annabelle Leigh (Billie Burke) is killed in a fight, miner John Rawson (Herbert Rawlinson) snatches her away from the scene and takes her to his cabin for the night. In the morning, she insists she was "compromised" by the situation, so he marries her. But after a spat, he tells her to leave and she goes to another city. Annabelle doesn't even know the name of the man she married; however, he strikes it rich and sends her money, which she spends on frivolous entertainment.

A doctor in New York City, who has had to raise his son without a mother since his wife died, struggles and sacrifices to be able to send the boy to a top-ranked, but expensive, medical university in Europe. His dream is that the boy will return to help him provide much needed medical care for the poor of his Lower East Side neighborhood.

In this reworking of "No, No, Nanette," wealthy heiress Nanette Carter bets her uncle $25,000 that she can say "no" to everything for 48 hours. If she wins, she can invest the money in a Broadway show featuring songs written by her beau, and of course, in which she will star. Trouble is, she doesn't realize her uncle's been wiped out by the Stock Market crash.

Big Steve Halloway, gambler and proprietor of New York's Horseshoe Cabaret, is in desperate need of money. He arranges for his fellow bookies, especially Sorrowful Jones, to each pay him $1,000 for his racehorse, Dream Prince, to lose. With all bets being placed at the window, Sorrowful encounters a gambler, having lost $500, wanting to place his bet but unable to come up with $20. Instead, he places his little girl, Marthy Jane, as security, or in bookie's terms a "marker". "Marky", as she comes to be known, winds up under the care of Sorrowful Jones and his lady friend, singer Bangles Carson.

Natali, a Hindu, marries an Englishman, Sir Christopher Madgwick. They have a daughter who is kidnapped by Natali's former suitor Sani. The girl is handed over to be trained as a vestal virgin. Natali dies and Madgwick returns to England, taking with him the precious ruby that Natali had snatched from Sani in a struggle. Years pass; Sir Christopher remarries and has two more children who mistreat him and Sani dies, revealing to the priests the location of the ruby, which he stole from them in the first place.

A playboy produces an airtight alibi when he is questioned about the murder of his wealthy aunt.

Kate Tarleton grows up on a Southern plantation and becomes engaged to her guardian, Dr. Robert Manning, a famous surgeon. When Robert, Kate, and her younger sister Mary Lou visit New York, where the doctor wishes to conduct medical experiments, the superstitious Kate goes to the home of a fortune-teller named Stella Hill. Stella, whose principal business is white slave trafficking, drugs Kate and forces her to work in a "den of vice," run by Stella and her accomplice Jimmy Bristol, where she contracts syphilis and goes insane. Robert, Detective Ellis, and a lawyer named Billy Meredith rescue Kate, who recovers her sanity but remembers nothing of her bondage.

A manicurist gives up the honest love of a barberr to become the mistress of a wealthy broker. But she comes to hate the man who has caused her downfall, and her loathing peaks during a dinner party he is holding. Other guests include three other men and their mistresses. Each young lady gets a $100 bill as a party favor, tucked away in one of the meal's several courses. The broker proudly brags about how each bill was obtained by giving the screws to the lower classes.

An arrogant young man leaves his Ohio home to make it big on Broadway in New York City when he inherits the family business and $1-million. However, things don't go quite according to his plans. After he blows most of the money, he returns to Ohio to try to sell the family business to raise more money, but complications ensue.

During World War I, a female agent tries to unmask a German spy.