In early 1860s New York, Irish immigrant Amsterdam Vallon is released from prison and returns to the Five Points, seeking revenge against his father's killer, William Cutting, a powerful anti-immigrant gang leader. He knows that revenge can only be attained by infiltrating Cutting's inner circle. Vallon's journey becomes a fight for personal survival and to find a place for the Irish people.

In many small episodes, various characters represent the typical vices and comedy of Italian society in early 2000.

Antonio, a representative of medical supplies with no success, finds a brilliant way to present himself to the customers and improve his sales: the special tiramisù made by his beautiful wife Aurora.

A young talented painter dreams of glory. A man promises it in exchange for his talent and his soul.