Frederick Fitzell is living his best life—until he starts having horrific visions of Cindy, a girl who vanished in high school. After reaching out to old friends with whom he used to take a mystery drug called Mercury, Fredrick realizes the only way to stop the visions lies deep within his own memories, so he embarks on a terrifying mental odyssey to learn the truth.

Working in the shadow of an esteemed police veteran, brash Detective Ezekiel “Zeke” Banks and his rookie partner take charge of a grisly investigation into murders that are eerily reminiscent of the city’s gruesome past. Unwittingly entrapped in a deepening mystery, Zeke finds himself at the center of the killer’s morbid game.

27 years after overcoming the malevolent supernatural entity Pennywise, the former members of the Losers' Club, who have grown up and moved away from Derry, are brought back together by a devastating phone call.

In the late '90s, Chester and Sonny are a long-term, committed, romantic couple. When Sonny wants to redefine their relationship, Chester, a painfully introverted cartoonist, starts sleeping with sex workers and discovers a new kind of intimacy in the process.

In the wake of her grandfather's death, Camila finds herself questioning her spirituality and the role it plays in her life while her family struggles with reconciling his abusive past.