The PFL 4 mixed martial arts event for the 2021 season of the Professional Fighters League was held on June 10, 2021. This was the fourth regular season event of the tournament and included fights in the Featherweight and Lightweight divisions. Boxing champion and Olympic gold medalist Claressa Shields made her MMA debut in the main event against Brittney Elkin.

The PFL 4 mixed martial arts event for the 2022 season of the Professional Fighters League was held on June 17, 2022 at the Overtime Elite Arena in Atlanta, Georgia. This marked the fourth regular season event of the tournament and included fights in the Lightweight and Light Heavyweight divisions.

The PFL 1 mixed martial arts event for the 2021 season of the Professional Fighters League was held on April 23, 2021. This was the first regular season event of the tournament and included fights in the Featherweight and Lightweight divisions. The event was headlined by a lightweight clash between the former UFC and WEC Lightweight champion Anthony Pettis and the UFC veteran Clay Collard.

PFL 3: 2023 Regular Season was a mixed martial arts event that took place on Friday, April 14, 2023 at the Theater at Virgin Hotels in Las Vegas, Nevada.

PFL 4: 2023 Regular Season was a mixed martial arts event that took place on Friday, June 23, 2023 at the Overtime Elite Arena in Atlanta, Georgia.

The PFL 1 mixed martial arts event for the 2022 season of the Professional Fighters League was held on April 20, 2022 at the Esports Stadium Arlington in Arlington, Texas. This marked the first regular season event of the tournament and included fights in the Lightweight and Light Heavyweight divisions. The event was headlined by a lightweight clash between Clay Collard and UFC veteran Jeremy Stephens, while 2021 champion Raush Manfio faces two-time UFC veteran Don Madge in the co-main event. The remaining two fights of the main card saw defending light heavyweight champion Antônio Carlos Júnior face off against Delan Monte, while 2019 champion Natan Schulte took on Olivier Aubin-Mercier. A lightweight bout between former WEC and UFC Lightweight Champion Anthony Pettis and Bellator veteran Myles Price was scheduled for the event but the bout was later moved to PFL 3.

PFL 9 was a mixed martial arts event produced by the Professional Fighters League that took place on August 23, 2023, at The Theater at Madison Square Garden in New York City, New York, United States. The event was headlined by a lightweight playoff bout between Clay Collard facing off against Shane Burgos in an attempt to reach the lightweight final.

The PFL 7 mixed martial arts event for the 2021 season of the Professional Fighters League was held on August 13, 2021. This was the start of the playoffs for the Welterweight and Lightweight divisions. This event aired on ESPN2, with the prelims on ESPN+.

PFL vs. Bellator: Champs was a mixed martial arts event co-promoted by Professional Fighters League and Bellator MMA that took place on February 24, 2024, at the Kingdom Arena in Riyadh, Saudi Arabia.

PFL 5 was a mixed martial arts event for the 2024 season of the Professional Fighters League was held on June 21, 2024, at the Huntsman Center in Salt Lake City, Utah, United States.