Valerio, a policeman and kickboxing champion, is about to become a father. His partner Valentina, with whom he is deeply in love, is expecting a child and the young couple's life seems to be going well. Valentina, however, cultivates the desire to become an actress and often finds herself meeting shady individuals such as the film producer and crime boss Sergio Bruschi. Valentina's sudden death following the unknowing intake of the so-called date rape drug during a meeting with Bruschi pushes Valerio to devote himself to an insane and terrible revenge.

Determined to exact his justice, Django faces dangerous challenges and bloody clashes to restore order in a territory dominated by lawlessness and injustice.