Continuing the tradition of national artist Ishmael Bernal's benchmark film Working Girls after 25 years, Working Girls of 2010 depicts the role of women in the new millennium. Seven women of different backgrounds, stories and personalities entwined in a colorful story of family, love and life.

Joan, a mother who works as a wedding dress designer, discovers that she has cancer. With declining health and limited time, Joan tries to do as much as she can for her daughter, Sarah.

A high school girl is paired with the stoic and handsome school know-it-all and finds that there is tenderness behind his cold exterior.

Miri is trapped in her past and this time her whole past comes crashing back into her life: old dead secrets, her dead parents, and even the walking dead. Miris return to Manila only brings her back to more trouble the personal kind. Even as a young girl, Miri believed she is responsible for her parents death and the guilt kept her from building healthy relationships with those around her specially with her younger brother Mark. Miri Alvarez, is one of the best agents of an international group organized to protect scientists and inventors from a tech-grabbing group called The Agency. But Miri is hot headed and refuses to follow orders. In one rescue operation, Miris refusal to follow protocol gets her long-time partner killed. Miri is suspended and sent back to Manila.