Francesco and Claudia are best friends. They're inseparable and tell each other everything, until another man enters the picture stealing Claudia's heart. Francesco then realizes that friendship between man and woman is a complicated thing.

After his ex-wife Addolorata's death, Giuseppe called "Cicci", a fifty years old manager, has to custody his son and doughter Matteo and Sara. Cicci has a long time relation with his partner Nikolas, a sincere and smart plumber. Cicci has three sisters Giuditta, Silvana and Norina: they grow him up as a son and they will put him in a very severe test on the way and how he has to grow up his childrens. The three women move to Cicci and Nikolas' house dictating their religious morals about the traditional family, inspired by don Paolo's words, a priest.

After his highly successful escape to Sardinia, Mr. Imbruttito returns to his native Milan, but within a short time, the company he has always worked for is acquired by a powerful American multinational, Blacksun. The new owners also promote a business model that is highly inclusive and sustainable. Mr. Imbruttito will lose his job, his home, and his family, finding himself forced to make ends meet by working as a delivery driver—precisely the very thing he always despised as a manager.