A man against capital punishment is accused of murdering a fellow activist and is sent to death row.

Eight years after the third film, the OSS has become the world's top spy agency, while the Spy Kids department has since become defunct. Retired spy Marissa is called back into action, and to bond with her new stepchildren Rebecca and Cecil, she invites them along to stop the evil Timekeeper from taking over the world.

Danny Ortega is imprisoned for a crime of justice at a very young age. After 17 years in prison, he returns to his town of Houston to find that crime and drugs have overturned what he once called home. When he attempts to rebuild his life, the lust for power overtakes him and launches him into the world that he always dreaded.