Mysterious experiments are going on at the Biogen 4 Research Labs. And now, those experiments...are loose! Monsters...creatures...hungry for flesh and blood.

Four friends are lost on a road trip, finding the house of a hidden cult that worships a being named Manos. They are led by the Master and his loyal servant, Torgo.

While helping the CIA to develop a deadly computer virus, a computer engineer finds himself as the target of an assassination.