Caro hasn't actually been able to do anything for a long time. As a nurse on a dementia ward, she has hardly taken any vacation in the last two years and has accumulated countless hours of overtime. But it is only when her dearest resident, Mrs. Rumi, dies that the barrel overflows: Instead of going to work the next morning, Caro goes to a locker at Frankfurt Central Station, takes out a packed, brand-new rucksack and simply sets off - without a destination, without a plan, without a cell phone and without any outdoor experience.

Hanni works around the clock as a cleaning lady. She has to because her husband, whom she loves, has not exactly shown himself to be a support financially. They also have their son Viktor. One day Hanni witnesses an attempted murder on an old lady. The killer now has an involuntary confidante and must eliminate her. But it doesn't come to that because Hanni uses her cleaning agents at the right moment, with her presence of mind. The killer falls unhappy and falls into a coma.

Isi and Ossi couldn't be any more different: She's a billionaire's daughter from Heidelberg, he's a struggling boxer from the nearby town of Mannheim. But when Isi meets Ossi, the two quickly realize that they can take advantage of one another: She dates the broke boxer to provoke her parents and get them to fund a long-desired chef training in New York. He tries to rip off the rich daughter to finance his first professional boxing match. Their plans soon develop into emotional chaos that challenges everything the two believe to know about money, career and love.

Young journalist Agatha switches from the sports department to the investigative department of a right-wing conservative news portal. She travels to rural Hesse to investigate the disappearance of a girl. In order to prove herself, she pressures the victim's relatives into making emotional statements. Agatha underestimates the questionable methods of the tabloid media and loses control.