In the year 2524, four centuries after humans started colonizing the outer planets, retired General James Ford gets called back into service when a hostile alien fleet attacks soldiers on a remote planet. The threat against mankind soon escalates into an interstellar war as Ford and a team of elite soldiers try to stop the imminent attack before it's too late.

Vengeance rides the open road when a young woman, traveling alone, encounters a renegade drifter and ends up in a fight for her life.