"Great Kills" is a dark comedy/mockumentary about a lonely small time hit man who is the subject of a documentary filmmakers. The show reveals a pathetically empty and misguided man and the callousness of the film makers who just want to get the shots, unmoved by torture and murder. The contradiction between personal life and job, and the apathy of the people making the documentary reflects satirically the dispassion of content creators in their relentless pursuit of content.

30 years after the events of The Brothers McMullen, romantic entanglements plague a now fiftysomething Barry McMullen and his twentysomething kids, as well as his brother Patrick and widowed sister-in-law Molly, who are also facing similar unexpected hurdles.