A UFC Middleweight Championship rematch between current champion Alex Pereira (also former Glory Middleweight and Light Heavyweight Champion) and former champion Israel Adesanya is expected to headline the event. The pairing previously met at UFC 281 in which Pereira captured the title by fifth round knockout. The two also previously met twice in kickboxing matchups. The first in April 2016 which Pereira won by unanimous decision. Their second meeting took place at Glory of Heroes 7 in March 2017 which Pereira won by third round knockout.

UFC Fight Night 201: Walker vs. Hill was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on February 19, 2022, at the UFC Apex facility in Enterprise, Nevada, part of the Las Vegas Metropolitan Area, United States. A lightweight bout between former UFC Lightweight Champion Rafael dos Anjos and Rafael Fiziev was expected to serve as the event headliner. However, the bout was postponed to UFC 272 due to visa issues with Fiziev. Instead, a light heavyweight bout between Johnny Walker and Jamahal Hill served as the main event.

Featherweight Calvin Kattar vs. Arnold Allen Welterweight Max Griffin vs. Tim Means Heavyweight Jared Vanderaa vs. Waldo Cortes-Acosta Middleweight Josh Fremd vs. Tresean Gore Light Heavyweight Dustin Jacoby vs. Khalil Rountree Jr.

UFC Fight Night 230: Yusuff vs. Barboza was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on October 14, 2023, at the UFC Apex facility in Enterprise, Nevada, part of the Las Vegas Metropolitan Area, United States. A featherweight bout between Sodiq Yusuff and Edson Barboza headlined the event.

UFC Fight Night 239: Tuivasa vs. Tybura was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on March 16, 2024, at the UFC Apex facility, in Las Vegas, NV, United States. A heavyweight bout between Tai Tuivasa and Marcin Tybura was scheduled for UFC 298 but the bout was moved in order to headline this event.

UFC on ESPN 59: Namajunas vs. Cortez was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on July 13, 2024, at the Ball Arena in Denver, Colorado, United States. A women's flyweight bout between former two-time UFC Women's Strawweight Champion Rose Namajunas and Tracy Cortez headlined the event.

UFC Fight Night 249: Dern vs. Ribas 2 was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on January 11, 2025, at the UFC Apex in Enterprise, Nevada, part of the Las Vegas Valley, United States. A women's strawweight rematch between Mackenzie Dern and Amanda Ribas headlined this event.

UFC on ESPN 64: Moreno vs. Erceg was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on March 29, 2025, at Arena CDMX in Mexico City, Mexico. A flyweight bout between former two-time UFC Flyweight Champion Brandon Moreno and former title challenger Steve Erceg headlined the event.

UFC on ESPN 72: Dolidze vs. Hernandez was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on August 9, 2025, at the UFC Apex in Enterprise, Nevada, part of the Las Vegas Valley, United States. A middleweight bout between Roman Dolidze and former LFA Middleweight Champion Anthony Hernandez headlined this event.