The year is 1764. For over a year, Josef has been leading a precarious life in Venice. He hopes to become an opera composer. The city, full of talented and already-established composers, seems closed to him. Looking for work as a violinist, he comes into the orbit of a rich young woman. Thanks to her, he gets the opportunity to play at salons. But his real opportunity arises when he becomes the lover of a libertine marquise. She teaches him worldly manners, rids him of signs of a provincial upbringing and introduces him to a hedonistic existence free from religious intolerance. Thus transformed, Josef gets an incan incredible commission: to write an opera for the San Carlo, Europe's largest theatre.

Lars, a male nurse from Saarbrücken, moves to Berlin with his lover, Roland. They begin to renovate an apartment and their happiness seems almost complete. What Roland doesn’t know is that, while secretly checking out Berlin’s night life, Lars is also experimenting with a deadly poison.