A group of influencers in a famed Hollywood apartment building pursue their dreams of social media stardom. The residents of 1660 Vine confront questions of fame, influence, identity, and mental health. All the while, the residents update their followers through vlogs, gaming streams, makeup tutorials, TikTok dances, songs, and pranks, as they navigate their search for identity, discovering the difference between who they present themselves to be, and who they really are.

New student Cady Heron is welcomed into the top of the social food chain by the elite group of popular girls called ‘The Plastics,’ ruled by the conniving queen bee Regina George and her minions Gretchen and Karen. However, when Cady makes the major misstep of falling for Regina’s ex-boyfriend Aaron Samuels, she finds herself prey in Regina’s crosshairs. As Cady sets to take down the group’s apex predator with the help of her outcast friends Janis and Damian, she must learn how to stay true to herself while navigating the most cutthroat jungle of all: high school.