Twenty-eight weeks after the spread of a deadly rage virus, the inhabitants of the British Isles have lost their battle against the onslaught, as the virus has killed everyone there. Six months later, a group of Americans dare to set foot on the Isles, convinced the danger has passed. But it soon becomes all too clear that the scourge continues to live, waiting to pounce on its next victims.

Untested American submarine commander, Capt. Joe Glass of the USS Arkansas, is on the hunt for a U.S. sub in distress in the Arctic Ocean. He soon learns a secret Russian coup is in the offing, a conspiracy that threatens to dismantle the world order. With crew and country on the line, Glass must coordinate with an elite group of Navy SEALs to sneak through enemy waters, rescue the kidnapped Russian president, and hopefully prevent World War III.