This film is based on the novel, Mrs. Mike, which is based on the real life woman, Kathy O'Fallon Flannigan. A Boston teenager is sent to live with her uncle in frontier Canada because of her fragile health. She eventually falls in love with one of the few young, white males in the region. They marry and depart for the northern wilderness to set up house and home. The rest of the movie is about her struggles and joys of living and travelling in this rugged country.

When Professor Marsh disappears while searching for the lost city of Lukachukai, his daughter enlists the help of the Three Mesquiteers.

A bumbling, long-winded and crooked Southern senator, considered by some as a dark horse for the Presidency, panics his party when his tell-all diary is stolen.

When Edward Creighton leads the construction of the Western Union to unite East with West, he hires a Western reformed outlaw and a tenderfoot Eastern surveyor. Preserved by the Academy Film Archive in partnership with Twentieth Century Fox Film Corporation in 2000.

Cheyenne joins El Diablo's gang looking for his long time missing wife and daughter. After saving Romero from the gang he returns to get Connie who he now realizes is his daughter. Captured, he escapes with Connie and they return to Romero's just ahead of El diablo's attacking gang.

After some gun play with a posse, the James Gang head for Quinto in a section of land which is not a part of America. Anyone there is beyond the law so the town is populated with outlaws. Next to arrive is Sheriff Rowley, following his brother whom the Gang have brought in injured. Rowley has no authority and gets on well enough with the James boys but is soon involved in other local goings-on, including a move to vote for annexation with Oklahoma which would allow the law well and truly in.

Ten years after the death of millionaire Cyrus Norman, his will is to be read out to his six relatives, including Joyce Norman and Wally Campbell. Organized by Norman's lawyer, Crosby, the six meet at Norman's eerie New Orleans Gothic mansion. During the reading, the superstitious housekeeper declares that someone will be dead by midnight. Wally fears for Joyce when she is declared the sole inheritor, but all are alarmed when Crosby turns up dead.

An American scout and his Indian friend help the English troops against the French during the French and Indian War.

Gun salesman Steve Farrell gets two of his new Colt .45 pistols stolen from him by ruthless killer Jason Brett but vows to recover them.

An Apache of mixed blood tries to make peace between Indians and whites.