Mary Smith decides after a lifetime of being a shut-in to do something wild while her father is out campaigning for the presidency, so she takes off for the family's home in West Palm Beach and inadvertently becomes romantically entangled with earnest cowboy Stretch Willoughby. Neither the dalliance nor the cowboy fit with the upper class image projected by her esteemed father, forcing her to choose.

Tom Grant has found a rich gold vein and Bart Eaton is after it. Tom's sister Mary heads for the gold fields and Eaton and his men follow. Eaton teams up with Ace Daggett who plans to doublecross him and get the gold for himself. They frame Tom for murder and then try to get him to sign over his claim. The famous scout Tex Houston is on hand, escaping the attempts on his life, saving Mary from various perils, and trying to bring in the real killer and clear Tom.

When a band of American Indians breaks a treaty with the federal government, U.S. Marshals Ken Maynard and Hoot Gibson hit the trail with captured outlaw Duke Dillon (Jack La Rue) to find out what sparked the uprising. They discover clues that point to corrupt Indian agent John Hampton (Kenneth Harlan), but meanwhile, the bandit Dillon pulls a fast one on the marshals, and soon everybody's getting ready for a showdown.

Jeff Scott is sent to investigate problems with wagon trains attempting to make the journey to Oregon. Sam Morgan has sent his henchmen, under lead-henchman Bull Bragg, to stop the wagon trains in order to maintain control of the fur trade in the area.

A cowboy is hired to track down a gang of rustlers, but gets involved with a beautiful girl trying to run her grandfather's gold mine and other outlaws who are trying to stop her.

Produced by Jack Schwartz for low-budget company Screen Guild, this mild Western starring the veteran Richard Arlen was apparently the first entry in a proposed series. Arlen played the title role, here assigned by the army to quell an Indian attack on the powerless settlers. The Indians are accusing Tom Russell (John Dexter) of murdering a member of the tribe, an act, as Buffalo Bill discovers, actually committed by a gang of outlaws hired by investment company owner J.B. Jordon (Frank O'Connor). Buffalo Bill Rides Again was soundly defeated by a low budget and slipshod direction by the veteran Bernard B. Ray. Popular B-Western villain Ted Adams disappeared mysteriously halfway through the film, only to be replaced by Edmund Cobb. Jennifer Holt, the daughter of Arlen contemporary Jack Holt and by far the busiest B-Western heroine of the 1940s, had little to do other than letting herself be kidnapped by evil Gil Patric.

On America's frontier, a St. Louis woman marries a New Mexico cattleman who is seen as a tyrant by the locals.

While Sam Houston in in the nation's capital trying to get Texas into the Union, his aide is trying to impose a self-serving tax on the use of the Santa Fe trail. The lady owner of a wagon train is using the trail, and a Texas Ranger comes to her assistance.

Frontiersman Kit Carson fights off Indian attacks on the trail to California.

An unknowing orphan idolizes the horse thief/mail robber who has shot his father.