George Bailey has spent his entire life giving to the people of Bedford Falls. All that prevents rich skinflint Mr. Potter from taking over the entire town is George's modest building and loan company. But on Christmas Eve the business's $8,000 is lost and George's troubles begin.

A New York radio personality travels to the small town of Fernville to oversee a contest to identify retired safecracker Jimmy Valentine, believed to be living there under an assumed name. The close-knit town of upstanding citizens is understandably upset by this venture, all the moreso when some of its citizens begin to be murdered. The radio personality and the local newspaper's young daughter collaborate on solving the murders while revealing Valentine, who has become one of the suspects.

A crime writer believes that a man imprisoned for committing the notorious "Flower Shop Murder" is innocent of the crime. He believes he knows who the actual culprit is, and sets out to befriend the man and get enough evidence to prove that he is the real killer.

An aspiring playwright gets a job in a New York City restaurant favored by celebrities in hopes of getting a break. Unfortunately, most of them believe that the waiter lacks the talent to make it big. Only an aspiring songwriter, and a former waitress who has become a famous Hollywood radio star, really believe in him. When the ex-waitress drops by the restaurant to say hello, she and the others decide to play a trick on an arrogant producer by making him believe the waiter has written a sure-fire hit. They succeed and the producer puts on the show. The singer gets to be the star. When the show becomes a smash, everyone is surprised. Songs include: "Hitchhike To Happiness," "For You And Me," "Sentimental," and "My Pushover Heart."

In New York, a surly, down-on-his-heels playwright meets a country girl who's giving up trying to act and returning home. He goes with her for inspiration when his agent convinces a stage star to take his next effort. When he returns to Broadway, his girl stays behind and starts seeing a local businessman.

Bodies start mysteriously disappearing from the city morgue. An investigator tries to determine what is going on.

Dr. Bartley Morgan covers up his profitable illegalities with the respectable veneer of a posh, highly profitable private practice, he runs with his nurse Margaret Hopkins. The FBI agent Robert Anders has to catch on to Morgan's illicit activities.

Kit Madden is traveling to Hollywood, where her best-selling novel is to be filmed. Aboard the train, she encounters Marines Rusty and Dink, who don't know she is the author of the famous book, and who don't think much of the ideas it proposes. She and Rusty are greatly attracted, but she doesn't know how to deal with his disdain for the book's author.

Returning from European exile where she avoided testifying against her criminal associates, a former singer with a tell-all diary is murdered to insure her silence.

A study of an amoral and sleazy defense lawyer who suddenly tries to "go straight" when he finds out that his tart wife is cheating on him; as well as the similarities he has in life with one of his clients.