Hugh Eltinge, a struggling artist, and Mark Dunbar, a genius of the pen, whom the world has as yet failed to reward, live together in MacDougal Alley. Across the hall is Doris Golden, a reporter on the Evening Star, who enthuses over the work of both. Mark's novel is sold and Hugh and Doris see a new Mark. Mark begs Hugh to allow him to stake him until his pictures sell, but pleasure in his new clothes and new popularity dwindle as he sees his old friends will not profit by them. A happy idea strikes him and he buys all of Hugh's paintings on exhibition at a local dealer, requesting that his name be not mentioned.

Madge Evans, World Film Corp. juvenile star, is sent to her Quaker grandparents, Timothy and Tabitha Mendenhall, when her father and mother go to serve in World War I. After bidding farewell to the World stars, Madge goes to her grandparent's home where she experiences stern discipline.

Following the death of her father, a Maine trapper, Jennie Cox moves to New York to earn her living.

Helene, who dances in a Greenwich Village cabaret accompanied on the violin by her grandfather, loses her job after his death. She then is hired as a portrait model by four artists--Jaffrey Darrel, Ned Lorrimer, Dick Turner and Stanley Sargent--all of whom become fascinated with her. Helene leaves the Village when Ned's jealousy disrupts the camaraderie of the quartet and becomes a stage star. Meanwhile, all of the artists have attained success except Jaffrey, who refuses to taint his art with commercialism.

A beautiful young French girl falls in love with a handsome New Englander, but when they marry and return to his family home, she finds that she does not fit in at all.

Gloria Swann becomes a dancer at the Palm Garden cabaret, trying to secure a better future and accepts Judge Malvin's offer of marriage despite the disparity of their ages and social stations. One day while Gloria and the judge are driving in the park, their car nearly runs over Larry Gibson, a soldier blinded in World War I. A remark by Gloria's friend, Teddy Safford, has aroused her maternal feelings, and the sight of the lonely soldier makes her even more sympathetic. Gloria takes Larry home and visits him daily. Larry plays banjo and writes songs about soldier life to cheer suffering servicemen.

Madge Black witnesses her best friend Nan Westland, kissing her husband, successful lawyer Jeffrey Arnold Black, a successful lawyer, and orders Nan from the house. Angered by her refusal to let him explain, Jeffrey leaves his wife and son David, Jeffrey meets Nan on a westbound train. Though he does not love her he offers his protection and the next year they welcome a son, William. Nan pleads with him to divorce Madge and marry her for the sake of their son, but he will refuse. Distraught, she marries Ben Richardson, a client of Jeffrey's client, leaving their son behind. Twenty years pass with David becoming a responsible adult while half-brother William now known as “Rodeo” becomes the leader of a lawless band of robbers. Meanwhile Ben Richardson and Nan have become owners of Chanceland, a gambling-house in Colorado and it is there that things reach a climax between the near identical brothers.