Two losers from Milwaukee, Coop and Remer, invent a new game combining basketball with the rules of baseball. When the game becomes a huge success, they, along with a billionaire's help, form the Professional Baseketball League where everyone gets the same pay and no team can change cities. When a rival owner wants to institute major rule changes, Coop and Remer's team is the only one standing in the way.

Follows the Boston Red Sox' Tim Wakefield and the New York Mets' R.A. Dickey - the only two major league pitchers who use the unpredictable knuckleball - during the 2011 season.