A mad scientist attempts to conduct a brain transplant with the supernatural powers of his captive.

Doofenshmirtz's latest "-inator" accidentally turns the citizens of Danville into contagious mindless repulsive pharmacists that look like him who run rampant all over town. Agent P and the kids must work together to save Danville and avoid becoming mindless repulsive pharmacists themselves.

When currently black-listed former child star Lissa Lliad is invited to screen test for a new superhero movie, she knows her big break has finally come. When she accidentally ingests a lot of LSD and makes the decision to be unstoppable and get to that audition no matter what, she embarks on an epic spiritual Odyssey which will confront her with the essence of who she is and transform her life in profound ways.