Kari, Lydia, Chloe and Molly play in a band called the Lolita Dolls. Their best friend Lenny accompanies them on a road trip. During this trip, they visit an old Sanitarium to shoot a music video. They were never seen again.

Tromaville’s local celebrity murderess, Dolly Deadly, is a shoo-in to win Serial Killer of the Year. Unfortunately, Slasharella has designs on the title and will stoop to the lowest of lows to take the crown. The two will drag Tromaville out and turn it upside down in their fight to the death, decimating the fictional city’s population all along the way.