Trick of the Witch is about a group of fashion models fighting a witchcraft curse while stranded at a secluded mansion.

Graciela receives a letter informing her that her husband Fidel has been released after six years in prison. She has waited for him all that time. They finally meet again.

To prevent the apocalypse, Rita must sacrifice a human at the secret altar in the Vertical Zone, where the monster lives. She doesn't believe it; however, in need of money to get her daughter back, she accepts to do the mission for a TV stunt and adventure show.

La Güera is the director of the "El Amanecer" rehabilitation center, where she is responsible for providing support to young people with drug addiction problems, following the "Twelve Steps" model. One day, La Güera's cousin asks her for help in admitting her young son Samuel to the center; La Güera goes to invite him to join the rehabilitation center. Samuel refuses and is taken there by force, which complicates his adjustment to the place. La Güera tries to encourage him and give him attention so that he can get used to his new surroundings. Everything seems to be going well when an armed group bursts in and takes several inmates, including Samuel. La Güera is forced to turn to one of her associates to get him back, revealing a dark secret.