Giuseppe Moscati, Doctor saint of Naples, was a doctor of the early twentieth century, from an aristocratic family devoted his career to serving the poor. The film focuses on the human side, partially leaving aside the spiritual part.

Set in 1970s Naples, bullied nine year-old Peppino is watching the world around him as his extended dysfunctional family change. Psychedelic flower power and hippie love is threatening the old traditional southern Italian family. Dad is having an affair and Mom has taken to her bed with depression. Super-mod brother and sister Titina and Salvatore take the boy under their wings, introducing him to demonstrations and love-ins, whilst caped superhero Gennaro visits Peppino even after being knocked down and killed by the number 12 bus. It is the imaginary appearances of this older superman cousin that help the nine-year-old navigate the complicated adult world.

The triumph of the designer Federico Marinoni in the world of Milanese fashion was marred by the tragic death of the maison's main model and the designer's muse, Alexandra Larsson, who was hit by a hit-and-run car while on her way to celebrate her consecration as a top model .