A man who lives in a house in a little town in Guatemala that has a reputation of being a sinful place, falls in love with a young girl.

Mano Negra sends a group of alien dwarves led by Aker to the state laboratory to kidnap the professor Arego and obtain the formula for the cultivation of microorganisms. The formula is divided among his four daughters and most work at a circus. The aliens take capsules that make themselves invisible, kidnap the girls and are eventually revealed to be blue-skinned, red-eyed monsters who are reduced to a puddle of green goo when killed.

The Count Cagliostro and scientist Raymond discovered a component that is only found in the mines of Guanajuato, this serves to create a formula to help them in their plans to conquer the world.