Two co-dependent high school seniors are forced to deal with separation anxiety after their plan to stage a booze-soaked party goes awry.

When actress Sarah Marshall dumps aspiring musician Peter Bretter for rock star Aldous Snow, Peter's world comes crashing down. His best friend Brian suggests that Peter should get away from everything and to fly off to Hawaii to escape all his problems. After arriving in Hawaii and meeting the beautiful receptionist Rachel Jansen, Peter is shocked to see not only Aldous in Hawaii, but also Sarah.

The brutal former heavyweight boxing champion Cleon "Slammin'" Salmon (Duncan), now owner of a Miami restaurant, institutes a competition to see which waiter can earn the most money in one night: the winner stands to gain $10,000, while the loser will endure a beating at the hands of the champ.

The lives of three women have a commonality: adoption. Karen is a physical therapist who regrets that, as a teenager, she gave up her daughter for adoption. Elizabeth was an adopted child and is now a successful lawyer, but her personal life lacks warmth. Lucy and her husband have failed to conceive and now hope to adopt a baby to make their family complete.

As they seek romance and sexual gratification, the lives of eight Los Angeles natives — including a teenager, a wedding photographer and a hotel desk clerk — converge on a carousel of carnal encounters.

Peter Klaven is a successful real estate agent who, upon getting engaged to the woman of his dreams, Zooey, discovers, to his dismay and chagrin, that he has no male friend close enough to serve as his Best Man. Peter immediately sets out to rectify the situation, embarking on a series of bizarre and awkward "man-dates."

Bright young student Raymond Aibelli is forced to sidetrack an important medical internship because his mother, Susan, is recovering from a broken leg. When he isn't tasked with the most mundane aspects of Susan's recuperation, Raymond finds distraction in a neighborhood girl, Toni Peck. But, as Susan begins relying on her son for both physical and emotional needs, Raymond starts developing disturbing and unwanted new yearnings.

After he's institutionalized in order to cover for his sister, a young man encounters a doctor who is turning his patients into flesh-eating psychopaths.

Benjamin has lost his wife and, in a bid to start his life over, purchases a large house that has a zoo – welcome news for his daughter, but his son is not happy about it. The zoo is in need of renovation and Benjamin sets about the work with the head keeper and the rest of the staff, but, the zoo soon runs into financial trouble.

A couple with a newborn baby face unexpected difficulties after they are forced to live next to a fraternity house.