At a reception for Mr. and Mrs. Vance Leighton, three men are discussing the effects of heredity in shaping the careers of children. To prove his contention that the theory of heredity is often demonstrated to be false, John Strong, a secret service agent, tells a true story: Two orphan sisters are adopted, one by society leaders, the other by a couple of crooks. The latter, known as "The Angel," becomes an expert pickpocket, while the other, Evelyn, becomes a reigning belle.

When a group of Arizona ranchers discover that an Eastern syndicate has cheated them out of options on their cattle, they send Buck Lindsay to New York to straighten things out.