Qüfür tells story of a sheikh who see the religion as a capital to exploit the masses. On the other hand, the paths of Fatma and Yusuf who are in a deep love will cross in this dervish lodge.

Doğa is a vibrant, university-aged young woman who suffers a tragic accident, resulting in spinal cord injury and loss of sensation below the waist. After this traumatic event, Doğa's life is completely transformed, and she loses her passion for life. She meets Yiğit, and through him, she tries to reconnect with life. Yiğit is a media-famous actor who has been betrayed by his fiancée and is eager to move past the emotional turmoil he is experiencing.