A confident and successful businessman slowly loses touch with reality through a psychotic episode, descending into madness. He befriends his briefcase which guides him through his journey, but other office supplies may not be as helpful.

When Kermit the Frog and the Muppets learn that their beloved theater is slated for demolition, a sympathetic human, Gary, and his puppet brother, Walter, swoop in to help the gang put on a show and raise the $10 million they need to save the day.