Rome and Juliet follows the romantic journey and soul mating of two straight women caught in a web of forbidden love. Juliet (a conservative pre-school teacher) is a bride to be who befriends and hires Rome (a liberated businesswoman) as her wedding planner. As they go through the preparations, Rome and Juliet develop a deep friendship, a soulful connection and a love that is physically consummated. But conflicts arise when Marc, the groom, who is a young politician, shockingly discovers the ongoing relationship between the two women. Angered and humiliated, Marc calls off the wedding and a huge scandal explodes, leaving Rome and Juliet in a state of emotional turmoil.

Angelo (Eigenmann) is an orphan who turns into a serial killer. Despite the efforts of rehabilitation, psychological turmoil still haunts and prevents him from living a peaceful and ordinary life. Faced with this reality, Angelo searches for a way to exorcise his personal demons. In the end, he gets his just reward when he crosses paths with a demon that he himself created.