Ms. Thing is a spoof on the late night TV infomercial. It follows the story of Jill, an emotionally volatile urban lesbian who is looking for love in all the wrong places. She’s a failure at dating. Her new, live-in relationship crumbles over a domestic difference. Just as she reaches an all-time low, stalking her ex on her social networking site, Jill’s knight in shining armor appears at the door. Not a man. Not even a woman. Jill’s prayers are answered by Ms. Thing, the perfect solution for women who are fed up with conventional relationships. Ms. Thing caters to her every need, provides unconditional love and long lasting sexual satisfaction.

When two small town waitresses have had it with living an uneventful existence, they take to the Highway to find fun and adventure. It doesn't take long to find trouble instead and a quick change of plans points them towards the border. A chance meeting with a lone hitchhiker changes their plans again and this time they find themselves a day late and dollar short. When it comes to running from the law, you always have to be one step ahead...