One Halloween night, a little girl visiting the Burber family's "House of Horrors" attraction is brutally hacked to pieces by their young son, Eddie. Having fled the scene, Eddie is taken away by his mother to live in solitude at a remote cabin. Twenty years later, Tophill State College's Sigma Phi fraternity are desperately trying to raise some cash, so they decide to throw a raucous fundraiser party for their peers. In the midst of the festivities, a mysterious figure arrives at the door, offering them the key to the old abandoned Burber house and suggesting that they turn it into a haunted house. Seizing the opportunity, the youngsters quickly set about transforming the property into an elaborate — and potentially lucrative — Halloween attraction. Little do they realize that Eddie Burber has returned home and intends to have some All Hallow's Eve fun of his own — setting up his own "Kill Room," where the line between fantasy and reality quickly becomes blurred...

A struggling freelance writer, while investigating the transvestite night life, stumbles across a serial killer in action. The two then strike up a bizarre partnership to document the killer's motives and handiwork as a possessed detective struggling with his own personal demons tries to solve the crimes.